Route notes
Why this routing works
This two-week itinerary is built as an open-jaw and multi-stop ticket: Charlotte to Rome, overland from Rome to Palermo, then a return from Catania back to Charlotte. That structure works well for travelers who want to avoid backtracking and keep the route moving in one direction through Italy.
With 3 nights in Rome at the front end, the schedule creates a clear starting point before the overland transfer to Palermo. From there, the itinerary shifts to a separate flight sector from Catania for the trip home, which is a practical way to connect two different points in Sicily without needing to return to the same airport.
Because Palermo is reached overland, the ticket separates the long-haul flights from the surface segment inside Italy. This is often the cleanest way to build a short multi-stop trip when one leg is better handled on the ground and the departure airport home is different from the arrival point.
Priced from $2,229 to $3,400 in economy, this October departure fits a compact two-week window and keeps the routing straightforward: one transatlantic arrival, one overland section, and one final international departure from a different city.